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KMID : 0367320010120020256
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Journal of the Korean Academy of Child and Adolescent Psychiatry
2001 Volume.12 No. 2 p.256 ~ p.262
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THE PRELIMINARY STUDY OF THE QUANTITATIVE MORPHOLOGIC ANALYSIS USING MRI OF THE LATERAL VENTRICLE IN EARLY-ONSET PSYCHOTIC DISORDER
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Lee Youn-Hee
Kang Min-Hee
Kim Chul-Eung
Lee Jung-Sub
Bae Jae-Nam
Hong Kang-E
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Abstract
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Objective : The enlargement of the lateral ventricle is well established finding in adult-onset schizophrenia, but in the patients with early-onset psychotic disorder (EOPD) is still controversal. To identify structural abnormalities of the lateral ventricle in patients with EOPD and difference of the brain developmental course in EOPD group, planimetrical assessment of the lateral ventricle was conducted by means of retrospective quantitative neuroimaging.
Methods : The brain MR images of 14 patients with EOPD (mean age 14.0± 2.1 years) who met the DSM-III-R diagnostic criteria for schizophrenia and bipolar disorder and 24 control subjects with simple headache (mean age 10.0± 2.1 years) were collected. Single best view for the lateral ventricle, one axial slice was selected for analysis. MR images were redigitalized with flatbed scanner and data were analyzed with NIIi IMAGE software.
Results : In the patients with EOPD, there were significant correlations between aging and lateral ventricular sizes and between aging and ventricular brain ratio (VBR) . The statistical significance of normal asymmetry of the lateral ventricle was not observed for the EOPD group. The EOPD group had larger lateral ventricular sizes and VBR than control group, but these results were not statistically significant_
Conclusion : These findings suggest that the brain abnormalities in patients with EOPD progress from the earlier course of the disorders and the course of brain development in EOPD group is different from control group.
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KEYWORD
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Early-Onset, Psychotic Disorder, Lateral Ventricle, MRI, Morphology
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